Job no: 0048911
Work type: Fixed Term
Division/Faculty: Faculty of Medicine, Dentistry and Health Sciences
Department/School: School of Biomedical Sciences
Role & Superannuation rate: Academic - Full time - 9.5% super
An opportunity exists for a highly motivated postdoctoral scientist to join the Griffin laboratory, which is part of the Bio21 Molecular Science and Technology Institute, at the University of Melbourne, Australia.
The Griffin Laboratory is focused on understanding the structures and signalling mechanisms of a unique family of cytokines that are implicated in a number of disease pathologies. Specifically, we are interested in understanding the complexities of protein-protein interactions, and how these define formation of cytokine-receptor complexes and activation of signalling pathways. These studies will contribute to the development of novel therapeutics.
The role of the postdoctoral fellow is to carry out cutting edge and innovative research in structural biology. The research position will work within projects focussing on the structure and interactions of a range of proteins including cytokines and their receptors. The work will involve protein expression and purification, as well as biochemical, biophysical and structural analyses. The incumbent will work on research projects either independently or in collaboration with others in the research group and in collaboration with research partners. They are expected to be self-motivated and to operate with minimal supervision under the general direction of the Laboratory Head and provide increasing input on scientific direction of their projects. Leadership in routine laboratory management duties and assistance of research students is also envisaged.
The host laboratory is situated in the Bio21 Molecular Science and Biotechnology Institute, which has excellent research facilities and a first-class working environment. The institute focuses applied technology and basic research for the generation of results that will improve our understanding of numerous diseases. The institute is a collaborative network that has a strong national and international reputation for performing highly influential research. The successful candidate will be embedded within the Biochemistry Department, University of Melbourne. The incumbent in this position is responsible to the laboratory head, Dr Michael Griffin (Supervisor). The appointee will interact with departmental administration, research scientists and students and will be expected to undertake appropriate laboratory and departmental administrative duties.
The position would appeal to a postdoctoral scientist with a strong background in biochemistry and structural biology, who is interested in understanding the structure/function of cytokine signalling molecules in order to define new therapeutic targets for human diseases. The successful candidate will be expected to utilise the Australian Synchrotron, and the institute’s dedicated Cryo-electron microscopy facility. The laboratory employs an extensive range of biochemical, biophysical and structural biology techniques. Experience in a broad range of protein expression systems and biochemical and biophysical skills are highly desirable.